you asked... Q&A: Can I use Splenda during pregnancy? Can I use Splenda (sucralose) during pregnancy? Want to participate? Log in to share your thoughts Re: Can I use Splenda (sucralose) during pregnancy? Yes, sucralose is just fine. The FDA says it's completely safe for pregnant women to consume. You can also have aspartame (NutraSweet or Equal Classic). The sweetener you should avoid is saccharin, which hasn't been proven safe, since it can cross the placenta, and doctors don't know exactly what kind of effect it has on a fetus. Ashley S. Roman, MD, ob-gyn and clinical assistant professor at New York University School of Medicine | June 17 , 2011 9:02 AM Want to participate? Log in to share your thoughts