you asked... Q&A: Is it safe to use vapor rub while I'm pregnant? Is it safe to use vapor rub while I'm pregnant? Want to participate? Log in to share your thoughts Re: Is it safe to use vapor rub while I'm pregnant? Yes, vapor rub is safe to use during pregnancy. Just follow the instructions properly. Laura Riley, MD, ob-gyn, Director of Labor and Delivery at Massachusetts General Hospital and author of You & Your Baby: Pregnancy Want to participate? Log in to share your thoughts